Published February 15, 2001
by Springer .
Written in English
|The Physical Object|
|Number of Pages||348|
Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products. The evolving role of natural products in drug discovery. The decreased emphasis in the pharmaceutical industry on the discovery of natural products can be attributed to several factors Cited by: drug discovery by playing a signiﬁcant role in the dis- covery and understanding of cellular pathwa ys that are an essential com ponent in the drug discovery process. Although traditionally natural products have played an important role in drug discovery, in the past few years most Big Pharma companies have either terminated or considerably scaled down their natural product operations. This is despite a significant number of natural product-derived drugs being ranked in the top 35 worldwide selling ethical drugs in , , and
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways. Natural products have played, and will continue to play, a key role in drug discovery and are therefore traditionally claimed as the cornerstones of drug discovery and development. Many drugs that are available in market today were discovered from natural sources [ 8 ]. An important example is the analgesic activity of aspirin [ 22 ], which is Cited by: 1. We are surely entering a New Golden Age of natural products drug discovery. Recent advances in microbial genomics and metagenomics have definitively revealed that the vast majority of earth’s biodiversity is yet to be exploited for natural products discovery (Charlop-Powers et al., ).Cited by: Natural products have been the source of most of the active ingredients of medicines. This is widely accepted to be true when applied to drug discovery in ‘olden times’ before the advent of high-throughput screening and the post-genomic era: more than 80% of drug substances were natural products or inspired by a natural is, however, arguably still true: comparisons of the Cited by:
NATURAL PRODUCTS Natural products are the richest source of biologically active compounds. Many today's medicines are either obtained directly from natural source or were developed from a lead compound originally obtained from a natural source. ROLE OF NATURAL PRODUCTS IN DRUG DEVELOPMENT The natural products can be classify into Natural products are a prime source of innovative molecular fragments and privileged scaffolds for drug discovery and chemical biology. Advanced machine-learning approaches can Cited by: The role of natural products in drug discovery and development Article (PDF Available) in World Journal of Pharmaceutical Research 4 February with 7, Reads How we measure 'reads'. This book systematically explores various natural products derived from microbes and plants, and which are potential sources for the development of new medications. Further, it presents advanced strategies used to discover novel natural products, and their biotechnological applications.